• 克里斯蒂娜·厄尔 grew up in Conway, AR, where she studied 化学 and Music at Hendrix College. Formative undergraduate research experiences in organic chemistry and neurobiology propelled her to a Ph.D. in 有机化学 at Stanford University, working in the laboratory of Professor Paul 行 to develop new oligomeric scaffolds for drug delivery applications. She then completed postdoctoral training in 化学ical 医学杂志ogy at Scripps 研究 in San Diego with Professors Jeff 凯利 and 卢克·怀斯曼, focusing on therapeutic approaches for protein misfolding diseases. Christina joined the 赌博娱乐平台网址大全 化学 faculty in 2015, where she leads an interdisciplinary undergraduate research program that applies the power of synthetic organic chemistry to impact related fields including polymer chemistry, 药物化学与生物学. Current major project areas include the development of fluorogenic radical polymerization reactions as platforms for biodetection, and prodrug strategies for disease-targeted therapeutic delivery. 除了研究, she is passionate about educating and mentoring the next generation of scientists, as well as serving the 赌博娱乐平台网址大全 and broader scientific communities.

    • Postdoc in 化学ical 医学杂志ogy, The Scripps 研究 Institute 
    • Ph.D. in 有机化学, Stanford University 
    • B.A. 亨德里克斯学院化学系 
    • Danyal Tahseen; 杰迈玛R. Sackey-Addo; 扎卡里·T. 艾伦; 约瑟夫T. 安德森; 约旦B. McMurry; 克里斯蒂娜B. 地中海. “Fluorogenic Monomer Activation for Protein-Initiated Atom Transfer Radical Polymerization” Org. Biomol. 化学. 2022, 20, 6257-6262.
    • 茱莉亚米. D. Grandjean; Aparajita Madhavan; Lauren Cech; Bryan O. Seguinot; Ryan J. Paxman; Emery Smith; Louis Scampavia; Evan T. Powers; 克里斯蒂娜B. 地中海; Lars Plate; Timothy P. Spicer; Jeffery W. 凯利; R. 卢克·怀斯曼. “Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming” Nat. 化学. 医学杂志. 2020, 16, 1052-1061. 
    • 乔纳森·E. Palmer; Breanna M. Brietske; Tyler C. 软化; Erik A. 布莱克伍德; 纳娑Garg; Christopher C. Glembotski; 克里斯蒂娜B. 地中海. “Reactive Oxygen Species (ROS)-Activatable Prodrug Strategy for Selective Activation of ATF6 Following Ischemia-Reperfusion Injury” ACS Med. 化学. 列托语. 2020, 11, 3, 292-297. 
    • 扎卡里·T. 艾伦; 杰迈玛R. Sackey-Addo; Madeline P. Hopps; Danyal Tahseen; 约瑟夫T. 安德森; Tyler A. Graf; 克里斯蒂娜B. 地中海. “Fluorogenic Atom Transfer Radical Polymerization in Aqueous Media as a Strategy for Detection” 化学. Sci. 2019, 10, 1017-1022.
    • 拉斯·普拉特;*克里斯蒂娜·B. *约翰·J·库里. Chen; Ryan J. Paxman; Ciara M. Gallagher; Franck Madoux; Joseph C. Genereux; Wesley Dobbs; Dan Garza; Timothy P. Spicer; Louis Scampavia; Steven J. Brown; Hugh Rosen; Evan T. Powers; Peter Walter; Peter Hodder; R. 卢克·怀斯曼; Jeffery W. 凯利. "Small Molecule Proteostasis Regulators that Reprogram the ER to Reduce Extracellular Protein Aggregation" eLIFE 2016, 5, e15550. 
    • 克里斯蒂娜B. * Lisa M. Ryno;* Lars Plate; Gareth J. Morgan; John D. Hulleman; Jeffery W. 凯利; R. 卢克·怀斯曼. “Unfolded Protein Response Activation Reduces Secretion and Extracellular Aggregation of Amyloidogenic Immunoglobulin Light Chain” Proc. 国家的. 阿德莱德大学. Sci. 美国 2014, 111, 13046-13051.
    • 马修D. Shoulders; Lisa M. Ryno; 克里斯蒂娜B. 地中海; Jeffery W. 凯利; R. 卢克·怀斯曼. “Broadly Applicable Methodology for the Rapid and Dosable Small Molecule-Mediated Regulation of Transcription Factors in Human Cells” J. Am. 化学. Soc. 2013, 135, 8129-8132.
    • 艾丽卡我. *克里斯蒂娜·B. 地中海;* Justin Edward; Matthew K. Kiesewetter; Jeff Simon; James L. Hedrick; Robert M. Waymouth; Paul A. 行. “Designed Guanidinium-Rich Amphipathic Oligocarbonate Molecular Transporters Complex, Deliver and Release siRNA in Cells” Proc. 国家的. 阿德莱德大学. Sci. 美国 2012, 109, 13171-13176.
    • 克里斯蒂娜B. 地中海; Brian M. Trantow; Fredrik Nederberg; Matthew K. Kiesewetter; James L. Hedrick; Robert M. Waymouth; Paul A. 行. “Oligocarbonate Molecular Transporters:  Oligomerization-Based Syntheses and Cell-Penetrating Studies” J. Am. 化学. Soc. 2009, 131, 16401-16403.
    • 克里斯蒂娜B. 地中海; Brian M. Trantow; Fredrik Nederberg; Matthew K. Kiesewetter; James L. Hedrick; Robert M. Waymouth; Paul A. 行. “Oligocarbonate Molecular Transporters” U.S. 专利7939621,2011.

    *表示同等作者
    Underline denotes 圣赌博平台网站大全 students or alumni

    • Fluorogenic Radical Polymerization
    • 若
    • 单体和前药合成
    • 靶向给药

    The 地中海 Lab has been supported by grants from federal agencies and private foundations including the National Science Foundation (CAREER and MRI programs), 韦尔奇基金会, the American 化学ical Society Petroleum 研究 Fund, the Arnold and Mabel Beckman Foundation, and the 圣安东尼奥 Area Foundation.

    • 有机化学
    • 化学合成
    • 神经化学
    • 生物化学实验室
    • 2021 National Science Foundation CAREER Award
    • 2021 圣赌博平台网站大全 Early Career Award for Distinguished 研究 and Teaching
    • 2012 NIH NRSA Ruth L. Kirschstein Postdoctoral Fellowship
    • 2011 Stanford University Sessler Graduate Student Leadership Award
    • 2009 Stanford University Linus Pauling Teaching Award